1-(Tetrahydro-2H-pyran)-3-trifluoromethyl-1H-pyrazole-5-boronic acid (abbreviated BTTP) is an organic compound. Its chemical formula is C11H15BF3N2O2.
BTTP is a white to light yellow crystalline powder, soluble in many organic solvents. It is a strong base ligand with high electrophilicity and nucleic acid.
BTTP is widely used as a catalyst in organic synthesis. It can catalyze asymmetric organic reactions such as asymmetric catalytic hydrogenation, asymmetric epoxidation of olefins, etc. In addition, it can also be used for metal complex catalytic reactions in organic synthesis.
The preparation method of BTTP is usually through the condensation reaction of aniline and formaldehyde, and then the oxidation reaction with oxalyl anhydride to obtain the target product.
For safety information, BTTP needs to be stored in a dark place and protected from moisture. Wear protective chemical gloves and goggles when using or operating the BTTP. Because it is an organic base, it may be irritating to the skin, eyes and respiratory system. Therefore, when handling and using BTTP, avoid direct contact with skin and eyes, and ensure a well-ventilated environment. When handling large amounts of BTTP, care should also be taken to prevent the inhalation of aerosol or dust. In case of accidental contact, rinse immediately with plenty of water and seek medical help.